StartUps thrives on Innovation. They can compete with mid/large organizations only if they remain innovative. Agile in general helps StartUps to innovate but it very much lies the way Agile is interpreted and implemented. Practitioners at times go overboard with practices of one of the methodology (say, Scrum, XP, Lean, Kanban etc) and loose the touch with agile values, context and reality. StartUps are always on resource-crunch, be it human power, systems, cash-in-hand etc and its not easy to keep best of processes with such constraints. Author has 3 startups of his own and have coached many startups/small companies in past and he would share his experiences/experiments with Agile keeping Innovation as the number one goal.